Adolescent idiopathic scoliosis (AIS), cerebrospinal fluid (CSF) flow and ciliopathy

Adolescent idiopathic scoliosis (AIS): new gene, new variants

Introduction Many chromosomic locations have been linked with the AIS, however, no causative genes have been clearly identified. We recently identified two regions (3q12.1 and 5q13.3) containing possibly causative gene(S) of AIS (Edery et al. 2011). Our recent work identified diseasecausing variants in a gene (that we called PFK2) in French AIS families (Patten et al. submitted 2014). We sought...

Neurotransmitter patterns in patients with adolescent idiopathic scoliosis (AIS)

Results Review of the completed urinalyses revealed a trend towards elevated histamine, elevated norepinephrine and decreased serotonin in the AIS patients as compared to non-scoliotics. Since these neurotransmitters are typically expressed in specific cortical areas, this pattern of imbalance may manifest as a functional hemisphericity, causing asymmetrical efferent responses to peripheral, af...

Adolescent Idiopathic Scoliosis

Adolescent Idiopathic Scoliosis

BACKGROUND Scoliosis refers to deviation of spine greater than 10 degrees in the coronal plane. Idiopathic Scoliosis is the most common spinal deformity that develops in otherwise healthy children. The sub types of scoliosis are based on the age of the child at presentation. Adolescent idiopathic scoliosis (AIS) by definition occurs in children over the age of 10 years until skeletal maturity. ...

Adolescent idiopathic scoliosis and osteopenia).

INTRODUCTION Generalized low bone mass and osteopenia in both axial and peripheral skeleton in adolescent idiopathic scoliosis (AIS) have been reported in literature. However, the exact mechanisms and causes of the bone loss in AIS are not identified yet. OBJECTIVE Therefore, this study examined the relationship between AIS and bone loss represented by: serum concentration of soluble receptor...